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Modelling
This project is investigating the effects of neural network
activity in the processing of sounds by the cochlear nucleus, the
first processing centre in the auditory system. We aim to show
that inhibitory inter-neurons enhance the input from the hearing
nerve to higher auditory centres in the brain. This mechanism is
particularly useful in processing speech sounds.
As yet, a firm hypothesis has not been established as to how
neurons in the cochlear nucleus utilise inhibitory inter-neurons
to enhance processing. Existing models of individual neuron
characteristics are unable to explain some functional behaviours
seen in animal studies. A greater understanding of the network
behaviour in the cochlear nucleus will contribute to our
understanding of sound processing by the human auditory system,
hence enable us to develop better strategies for cochlear implant
processing.
Optimisation
Synaptic properties within microcircuit models
are highly influenced by driven input and background noise
sources; therefore optimization routines must be carefully
designed to be robust to trial-to-trial variation and maintain
parameter sensitivity of the cost function around the target data.
This study presents a method for optimizing topographically
ordered biological neural networks using genetic algorithms.
Neural responses are generated with surrogate parameters and the
ability of the algorithm to find the known neural parameters being
investigated in a current study.
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